Latent Myeloproliferative Neoplasm as a Cause of Idiopathic Splanchnic Vein Thrombosis: The Role of JAK2V617F Mutation and Bone Marrow Biopsy Evaluation
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چکیده
Abbreviations: MPN: Myeloproliferative Neoplasms; PV: Polycythemia Vera; ET: Essential Thrombocythemia; PMF: Primary Myelofibrosis; CBC: Complete Blood Count; SVT: Splanchnic Veins Thrombosis; PVT: Portal Vein Thrombosis; BCS: Budd Chiari Syndrome; AST: Aspartate Amino Transferase; ALT: Alanine Aminotransferase; WBC: White Blood Cell count; CT: Computed Tomography; Ig: Immunoglobulin; ADP: Adenosine Diphosphate; PFA-100: Platelet Function Analyzer; Epi: Epinephrine; INR: International Normalized Ratio; CD: Cluster of Differentiation; BCR-ABL: Breakpoint Cluster Region-Abelson; AML: Acute Myelogenous Leukemia; vWD: Von Willebrand Disease; LDH: Lactate Dehydrogenase
منابع مشابه
Evaluation of JAK2V617F mutation prevalence in myeloproliferative neoplasm by AS-RT-PCR
Abstract Objective JAK2 is a non-receptor tyrosine kinase that plays a major role in myeloid disorders. JAK2V617F mutation is characterized by a G to T transverse at nucleotide 1849 in exon 12 of the JAK2 gene, located on the chromosome 9p, leading to a substitution of valine to phenylalanine at amino acid position 617 in the JAK2 protein. Methods In this study we evaluated RNA from 89 pati...
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